Key facts of the CoQ10 training brought to you by Sanofi Consumer Healthcare

Feb 12, 2019

Coenzyme Q10 is a fat-soluble compound primarily synthesized by the body and can also be obtained from certain foods we eat.2b Coenzyme Q10 is required for energy production in cell membranes and lipoproteins.14eCoQ10 is found in relatively higher concentrations in cells with high energy requirements such as the heart, liver, muscle, and pancreas.14f

The rationale for the use of CoQ10 as a supplement is based on its role in energy production and its antioxidant properties. CoQ10 levels naturally decreases as we age and also decreases with certain disease states.CoQ10 levels can also decrease from the use of certain medications.3b

CoQ10 supplementation could be important in statin-intolerant patents as well as in the elderly, where CoQ10 levels are generally low. 3bStatins can reduce serum CoQ10 levels from 16 % up to 54%, this may contribute to statin-induced myopathy, a condition in which a person experience muscle related side effects.10,20Some of the side effects patients on statin therapy may suffer from and CoQ10 supplementation may relieve are muscle pain, muscle weakness, muscle cramps and tiredness.12CoQ10 supplementation may offer an alternative to stopping treatment of these vital drugs.3bAlways consult your doctor before you stop conventional treatment.

Low levels of CoQ10 have been related to the higher oxidative stress produced during ageing and different diseases.Due to the antioxidant function of CoQ10, CoQ10 may play a role in the improvement of circulation in consumers who suffer from high oxidative stress levels like patients suffering from diabetes, high cholesterol and hypertension.Oral CoQ10 supplementation may be a viable strategy for diseases related with reduced CoQ10 levels.3c

CoQ10 has an excellent safety record and is well tolerated at high doses over long periods of use with limited side effects.CoQ10 doses of 100–200 mg/day are recommended for the treatment of chronic heart disease.Maximum absorption of CoQ10 can be achieved if taken with meals that contain fat.14b Patients on warfarin should be monitored frequently.14dSince there is no data on the safety of CoQ10 supplementationinpregnant and lactating women, its use is not recommended for these populations. 19a

This was brought to you by Sanofi Consumer Heathcare a division of Sanofi and the manufacturers of Stat10Choice. Stat10Choice contains 150mg CoQ10 and is taken once a day with food.19b

References

  1. Langsjoen, P.H. “Introduction to CoQ10” , assessed online 3 July 2014 https://www.grc.com/sr6dev/misc/coq10/coenzyme%20q10.pdf
  2. 14b,d,e,f. Shinde S, Patil N, Tendolkar A. Coenzyme Q10: A Review of Essential Functions. The Internet Journal of Nutrition and Wellness. 2005 Volume 1 Number 2
  3. 3b,cVillalba JM, Parrado C, Santos-Gonzales M, Alcain FJ. Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Expert Opin. Investig Drugs. 2010; 19(4): 535 – 554
  4. 10 Marcoff L, Thompson PD. The role of Coenzyme Q10 in Statin-Associated Myopathy. A Systematic review. Journal of the American College of Cardiology. 2007; Vol 29 (23) p2231-2237
  5. 20Sathasivam S, Lecky B. Statin induced myopathy. A clinical review.BMJ 2008; 337 doi: http://dx.doi.org/10.1136/bmj.a2286 (Published 06 November 2008) Cite this as: BMJ 2008;337:a2286
  6. 12 Fedacko J, Pella D, Fedackova P, Hänninien O, Tuomainen P, Jarcuska P, Lopuchovsky T, Jedickova L, MerkovskaL,Littaru GP. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can J PhysiolPharmacol. 2013;91(2):165-70
  7. 19a,b Stat10Choice Package Insert

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